Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infectionArticle Published on 2022-10-012023-07-09 Journal: The Journal of Infection [Category] COVID19(2023년), [키워드] ACE2 Ang II SARS-CoV-2 Spike. [DOI] 10.1016/j.jinf.2022.06.030 PMC 바로가기
Plasmatic renin-angiotensin system in normotensive and hypertensive patients hospitalized with COVID-19Research article Published on 2022-08-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 바이오마커, 치료기술, [키워드] ACE ACE2 ACE2 expression ACE2 protein acute respiratory syndrome Analysis Ang II angiotensin Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitors blockade cause circulating control group coronavirus COVID-19 COVID-19 group COVID-19 patient COVID-19 patients enzymatic activity etiological agent healthy healthy subjects Hospitalized hypertension hypertensive hypertensive patient investigated medications normotensive not different Patient patients protein level RAS receptor remained renin-angiotensin system reported Result significantly Support treated Treatment were excluded were measured with COVID-19 [DOI] 10.1016/j.biopha.2022.113201 [Article Type] Research article
Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System새로운 안지오텐신 수용체 차단 약물, 비사르탄, COVID-19 치료와 관련된 작용: 안지오텐신 수용체의 편향 작용 및 레닌 안지오텐신 시스템에서 네프릴리신의 유익한 효과Article Published on 2022-07-292022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 3CLpro ACE2 Action activated activating active site Agonism ANG Ang II angiotensin angiotensin converting enzyme Angiotensin II angiotensin II receptor blockers (ARBS) angiotensin II receptors Angiotensin receptor blockers anionic ARB/NEP docking ARBs AT1 AT2 biased agonism binding biphenyl bisartans blocker blocking cells charge relay system (CRS) complementary COVID-19 COVID-19 virus DNA driven by edema Effect endopeptidase enzyme Evidence explained furin G protein Human genome humoral hypertension in silico inhibit inhibiting inverse agonist involved modulating molecular molecular dynamics Molecular dynamics (MD) mRNA neprilysin novel opposite peptide peptides Protein Pulmonary edema RAS receptor Receptor Blockers receptors Renin SARS-COV-2 infection Sartans. Screening Serine serine proteases switching System tetrazole this system Treatment Vasoactive viral entry Zinc [DOI] 10.3390/molecules27154854 PMC 바로가기 [Article Type] Article
Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizerCOVID-19 질병에 대한 에어로졸 중재 개발: 분무기를 통해 투여되는 가용성 ACE2(APN01)의 내약성Article Published on 2022-07-112022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 비임상, 임상, [키워드] ACE2 Administered administration aerosol aerosolization airways Ang II angiotensin binding binding activity breath catalytic caused cleavage clinical trial Concentration conducted COVID-19 Critical deregulated development Efficacy enzymatic activity evaluated Evidence evidence of feasible healthy volunteer healthy volunteers in vitro individual Infection initiated Intervention Kinin limit lung lung damage mitigate mouse model neutralization neutralize notable Pathways phase preliminary evidence RAS RAS activity recombinant ACE2 Renin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Signaling soluble ACE2 Spread subsequent Tolerability toxicities virus [DOI] 10.1371/journal.pone.0271066 PMC 바로가기 [Article Type] Article
Sars-Cov-2 Spike Protein-Induced Damage of hiPSC-Derived CardiomyocytesSars-Cov-2 스파이크 단백질에 의한 hiPSC 유래 심근세포 손상Article Published on 2022-07-012022-09-12 Journal: Advanced Biology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 alteration Ang II angiotensin-converting enzyme 2 Cardiomyocytes chromatin cleavage complex connexin Culture damage downregulated Effect endocytic expression fluctuation functional hiPSC host cells incubated investigated margination molecular pluripotent stem cell Protein Proteins receptor SARS-CoV-2 spike Spike protein spike protein. Spike proteins Structure subunit the spike protein undergo virus while [DOI] 10.1002/adbi.202101327 PMC 바로가기 [Article Type] Article
Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury급성 폐 손상에 대한 항 코비드 -19 전통 중국 처방, Keguan-1의 억제 효과 및 메커니즘Article Published on 2022-03-012022-08-31 Journal: Journal of ethnopharmacology [Category] MERS, SARS, 비임상, 치료제, [키워드] acute lung injury Adhesion Molecule Administered administration ALI Alpha ameliorated analysed Ang II Angiotensin II ARDS BALF breath cadherin chemokine Chinese claudin Clinical treatment clinical trial collected coronavirus coronavirus disease COVID-19 demonstrated Diseases Effect ELISA Emerging infectious diseases Endothelial cell endothelial injury expression Factor High dose ICAM-1 IL-1β IL-6 IMPROVE incidence Infectious diseases Inflammation Inflammatory Inflammatory factor inflammatory factors inflammatory protein inhibited Injury interleukin intratracheal instillation Keguan-1 keratinocyte lipopolysaccharide low dose LPS lung Lung injury lung tissue lung tissues Macrophage material mechanism medium dose mice Necrosis neutrophil Neutrophils patients with COVID-19 progression proinflammatory protective mechanism Protein provide pulmonary Pulmonary vascular endothelial injury. randomised reduced reducing Registered Seven significantly Support survival rate TCM therapy tight junction TNF-α Traditional Chinese medicine treat Tumour necrosis factor alpha Vascular VE-cadherin was used western blotting [DOI] 10.1016/j.jep.2021.114838 PMC 바로가기 [Article Type] Article
The interacting physiology of COVID-19 and the renin-angiotensin-aldosterone system: Key agents for treatmentCOVID-19와 레닌-안지오텐신-알도스테론 시스템의 상호작용 생리: 치료의 핵심 인자Review Published on 2022-02-012022-09-11 Journal: Pharmacology Research & Perspectives [Category] COVID19(2023년), SARS, 신약개발, [키워드] ACE2 Activation aldosterone alteration Ang II angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 Arm circulating circulation circulatory system contrary conversion COVID-19 destruction dysregulated Effect Effects enzyme fluids homeostasis Host host response Infection Inflammation Inflammatory response Injury limit maintain metabolism Pathogenesis pathogenesis of COVID-19 peptide pro-inflammatory action pro-inflammatory actions RAAS receptor regulated Renin renin-angiotensin system renin-angiotensin-aldosterone system respond responsible SARS-CoV-2 steroid steroid hormone Therapies therapies. tissue tissue perfusion trauma Treatment turn viral infection Volume [DOI] 10.1002/prp2.917 PMC 바로가기 [Article Type] Review
Bulbus Fritillariae Cirrhosae as a Respiratory Medicine: Is There a Potential Drug in the Treatment of COVID-19?Pharmacology Published on 2022-01-202022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] “cytokine storm” ACE ACE2 alkaloids Ang II Anti-inflammatory antioxidant effects ARDS Asthma biological significance bulbus fritillariae cirrhosae Characteristics Chinese COPD COVID-19 Degradation drug Drug discovery exhibit explained Inflammatory response Intervention involved lung cancer Lung disease MAPK signaling mechanism Medicine molecular NF-κB Pathways Potential produced pulmonary tuberculosis RAS regulate renin-angiotensin system Research respiratory Respiratory disease respiratory diseases SARS-CoV-2 SARS-COV-2 infection signaling pathway signaling pathways STAT targets therapeutic therapeutic drug therapeutic potential Treatment [DOI] 10.3389/fphar.2021.784335 PMC 바로가기 [Article Type] Pharmacology
Sex differences in the lung ACE/ACE2 balance in hypertensive ratsCardiovascular System & Vascular Biology Published on 2021-12-222022-10-28 Journal: Bioscience Reports [Category] COVID-19, [키워드] accelerate ACE ACE2 ACE2 gene ACE2 mRNA ACE2 protein Ang II Angiotensin II Angiotensin-(1-7) Angiotensin-converting enzyme angiotensin-converting enzyme 2 blood pressure coexpressed Concentration conducted coronavirus disease COVID-19 down-regulation evaluated expression female four group Genotype-Tissue Expression project Human hypertension hypertensive hypertensive patient Hypothesis lung Lung injury Lungs male Male sex mRNA level normotensive occur pathway promote Protein reduced respiratory infections sexual dimorphism significantly higher subjects tested tissue damage tissues [DOI] 10.1042/BSR20211201 PMC 바로가기 [Article Type] Cardiovascular System & Vascular Biology
The Identikit of Patient at Risk for Severe COVID-19 and Death: The Dysregulation of Renin-Angiotensin System as the Common ThemeReview Published on 2021-12-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome adverse outcome Ang II Angiotensin 1-7 Arm Arterial hypertension binding cardiovascular disease cardiovascular morbidity caused characterized common conditions coronavirus coronavirus disease COVID-19 Diabetes Mellitus down-regulation dysregulation Evidence Health hospitalized patients hypertension increased risk Infection Lung injury Male sex metabolic condition metabolic syndrome obesity Older age opposite overweight pandemic pathophysiological Patient phenotype prevalent RAS receptor reducing renin-angiotensin system SARS-CoV-2 severe COVID-19 syndrome System traits type 2 diabete virus widespread [DOI] 10.3390/jcm10245883 PMC 바로가기 [Article Type] Review